3立方衬氟反应釜
设备型号：PTFE-Lined Reactor Series设计标准：GB/T 25025-2019《搪玻璃设备》 | ASME BPE (生物制药设备规范)
设备型号：PTFE-Lined Reactor Series设计标准：GB/T 25025-2019《搪玻璃设备》 | ASME BPE (生物制药设备规范)
设备型号：PTFE-Lined Reactor Series
设计标准：GB/T 25025-2019《搪玻璃设备》 | ASME BPE (生物制药设备规范)
部件 | 材质选项 | 特性说明 |
基体壳体 | Q235-B / 304 / 316L 不锈钢 | 承压结构层，机械强度≥200MPa |
内衬层 | 聚四氟乙烯（PTFE） | 厚度 2.5~4.0mm，纯度≥99.9%，无孔隙烧结工艺 |
过渡层 | PFA（可熔性聚四氟乙烯） | 用于PTFE与金属基体热膨胀补偿（选配） |
密封系统 | PTFE包覆O型圈 + 柔性石墨填料 | 耐温 -196℃~250℃，耐压 0.6MPa（静态）/0.4MPa（动态） |
注：针对氢氟酸等强渗透介质，可升级为 PCTFE（聚三氟氯乙烯）内衬 或 ETFE（乙烯-四氟乙烯共聚物）涂层。
松衬法：PTFE板材焊接成型后装入壳体，适用常压/低压容器
紧衬法：PTFE粉料模压烧结→金属壳体热胀冷缩嵌套，耐压等级 ≤0.8MPa
等压成型（高端型）：PTFE悬浮树脂喷涂+高温烧结，无接缝，耐真空 -0.098MPa
组件 | 设计特点 |
搅拌系统 | 锚式/桨式+PTFE包覆316L轴芯，机械密封（双端面） |
换热结构 | 夹套（蒸汽/导热油）或内盘管（PTFE衬里），传热系数 60~100 W/(m²·K) |
接口法兰 | DIN/ANSI标准，PTFE翻边密封，防腐蚀介质渗漏 |
视镜/人孔 | 钢化硼硅玻璃 + PTFE密封圈，耐压0.4MPa |
耐受介质：
强酸：浓硫酸（98%）、盐酸（37%）、硝酸（68%）、氢氟酸（40%）
强碱：浓氢氧化钠（50%）、液氨
有机溶剂：苯、氯仿、乙酸乙酯
耐蚀等级：优于哈氏合金C276，使用寿命≥10年（酸性环境）
PTFE表面接触角＞110°，不粘附物料
符合FDA 21 CFR 177.1550 食品/药品级认证
操作范围：-50℃（深冷） ~ +200℃（蒸汽加热）
热循环次数＞5000次（-50℃↔200℃）无衬层剥离
对比项 | 衬四氟反应釜 | 哈氏合金反应釜 |
设备成本 | ¥200,000~500,000 | ¥800,000~2M+ |
停机维修频率 | 3~5年/次 | 1~2年/次 |
备件更换成本 | 衬里局部修复 | 整体更换 |
精细化工：硝化/磺化反应、氯化物合成
制药：API中间体结晶、高纯电解质溶液
湿法冶金：贵金属萃取、酸浸提纯
环保：废酸回收、含氟废水处理
参数 | 标准值范围 | 可定制扩展 |
容积 | 50L ~ 20,000L | 30,000L (最大) |
设计压力 | -0.1 ~ 0.8 MPa | 1.0 MPa (紧衬) |
表面粗糙度 (Ra) | ≤0.8μm | ≤0.4μm (PFA抛光) |
防静电设计 | 内嵌铜网 (可选) | 符合ATEX认证 |
质量保障体系
检测标准：
衬层厚度超声检测 (ISO 21809-2)
电火花针孔检测 (≥5kV/mm)
100% 氦质谱检漏 (泄漏率≤1×10⁻⁹ mbar·L/s)
Model: PTFE-Lined Reactor Series
Design Standards: GB/T 25025-2019 (Glass-Lined Equipment) | ASME BPE (Bioprocessing Equipment)
Component | Material Options | Key Properties |
Base Shell | Q235-B / 304 / 316L Stainless Steel | Structural layer, mechanical strength ≥200 MPa |
Lining Layer | Polytetrafluoroethylene (PTFE) | Thickness: 2.5~4.0mm, purity ≥99.9%, porosity-free sintering process |
Transition Layer | PFA (Perfluoroalkoxy) | Thermal expansion compensation between PTFE and metal (optional) |
Sealing System | PTFE-encapsulated O-rings + Flexible Graphite Packing | Temp. range: -196℃~250℃, Pressure: 0.6MPa (static)/0.4MPa (dynamic) |
Note: For highly permeable media (e.g., hydrofluoric acid), upgrade to PCTFE (Polychlorotrifluoroethylene) or ETFE (Ethylene Tetrafluoroethylene) coating.
Loose Lining: PTFE sheets welded & inserted into shell (for atmospheric/low-pressure vessels)
Compression Lining: PTFE powder molded/sintered → thermally shrunk onto metal shell (pressure rating ≤0.8MPa)
Isostatic Molding (Premium): PTFE suspension sprayed + sintered, seamless, vacuum resistance -0.098MPa
Assembly | Design Features |
Agitation System | Anchor/paddle type + PTFE-clad 316L shaft, dual mechanical seals |
Heat Exchange | Jacket (steam/thermal oil) or PTFE-lined coil, heat transfer coefficient: 60~100 W/(m²·K) |
Flange Connections | DIN/ANSI standard, PTFE flanged seal, anti-leakage |
Sight Glass/Manway | Tempered borosilicate glass + PTFE gasket, pressure resistance: 0.4MPa |
▶ Extreme Corrosion Resistance
Compatible Media:
Strong acids: Conc. H₂SO₄ (98%), HCl (37%), HNO₃ (68%), HF (40%)
Strong alkalis: NaOH (50%), liquid ammonia
Organic solvents: Benzene, chloroform, ethyl acetate
Performance: Outperforms Hastelloy C276, service life ≥10 years (acidic environments)
▶ High Purity & Contamination Prevention
PTFE contact angle >110°, non-stick surface
Complies with FDA 21 CFR 177.1550 (food/pharmaceutical grade)
▶ Broad Temperature Tolerance
Operating Range: -50℃ (cryogenic) ~ +200℃ (steam heating)
Withstands >5,000 thermal cycles (-50℃↔200℃) without delamination
▶ Cost Efficiency
Comparison Item | PTFE-Lined Reactor | Hastelloy Reactor |
Equipment Cost | ¥200,000~500,000 | ¥800,000~2M+ |
Maintenance Frequency | 3~5 years | 1~2 years |
Part Replacement | Localized repair | Full vessel replacement |
Fine Chemicals: Nitration/sulfonation, chloride synthesis
Pharmaceuticals: API intermediate crystallization, high-purity electrolyte solutions
Hydrometallurgy: Precious metal extraction, acid leaching
Environmental: Waste acid recovery, fluoride-containing wastewater treatment
Parameter | Standard Range | Custom Options |
Volume | 50L ~ 20,000L | Up to 30,000L |
Design Pressure | -0.1 ~ 0.8 MPa | 1.0 MPa (compression lining) |
Surface Roughness (Ra) | ≤0.8μm | ≤0.4μm (PFA polished) |
Anti-static Design | Embedded copper mesh (optional) | ATEX certification |
Quality Assurance System
Testing Standards:
Lining thickness UT (ISO 21809-2)
Spark testing (≥5kV/mm)
100% Helium leak detection (≤1×10⁻⁹ mbar·L/s)
Document Note: This specification can be supplemented with corrosion resistance data and design calculations based on specific process conditions. Supports EPC project integration.
For detailed engineering parameters, please provide operational data (media composition, temperature/pressure profiles, etc.).
Nozzle 管口 | Connection standard 连接尺寸 | Application用途 |
a | / | Manhole 人孔 |
b | HG/T20592-2009 | Agitator hole 搅拌孔 |
c | HG/T20592-2009 | Temperature hole 温度计口 |
d | HG/T20592-2009 | Discharge hole 排净口 |
e | HG/T20592-2009 | Reserve hole 备用口 |
f | HG/T20592-2009 | Pressure gauge 压力表口 |
S1-2 | / | Sight glass hole 视镜口 |
H1-4 | HG/T20592-2009 | Jacket inlet and outlet hole 夹套进出口 |
K1-2 | HG/T20592-2009 | Reserve hole 备用口 |
m | Inner screw, G1/2” | Jacket vent hole 气体出口 |